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CS-2400/CS-2500

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The successors of the first coagulation analyser possessing a multi-wavelength analysis technology, the CS-2400 and CS-2500 systems allow medium-high volume laboratories to perform routine and specialised testing in a single analyser.

CS-2400 / CS-2500

Mid volume, fully automated haemostasis benchtop analyser that features advanced technology such as multi-wavelength detection and HIL check. It offers a wide range of assays utilising four detection methods: clotting, chromogenic, immunological (turbidimetric) and aggregometry.

Registered Under Act 737 (IVDC8558421-69696)

The CS-2400 and CS-2500 systems perform a wide spectrum of routine and specialised testing with consistent accuracy and reliability, usability designed with Medical Technologists in mind, and provide extra support to laboratory accreditation and documentation requirements.

Consolidation of routine and specialised testing

  • The CS-2400 and CS-2500 systems automates testing of special parameters such as FXIII activity, platelet-based von Willebrand cofactor activity, platelet aggregation to ADP, epinephrine, collagen, arachidonic acid and ristocetin in a single analyser.
  • The 1st and 2nd derivatives are available from the clot waveform analysis for research in potential clinical utility of evaluating coagulation function in various bleeding disorders, especially Haemophilia A, B, and monitoring bypass therapy1.

Consistent accuracy and reliability

  • Sysmex’s proprietary multi-wavelength analysis technology automatically uses optimal wavelength for each measurement parameter to reduce the effects of interfering substances on the absorbance spectra, or in specific sample conditions such as low fibrinogen level or severe lipaemia to deliver accurate result on every test run.
  • Sample integrity such as the presence of interfering substances in the sample – haemolysis, icterus, lipaemia (HIL) and primary tube sample volume is checked before analysis. Results are flagged if the sample is of questionable quality to ensure only reliable results are reported by laboratories.

Advanced usability

  • Intuitive cap-piercing technology on the CS-2500 system allows mix of capped and uncapped tubes and cups on the same rack and reduces sample processing time.
  • Onboard capacity of up to 40 reagents (cooled at 10°C) and five additional buffer positions, accessible reagent table for continuous loading of reagents and consumables and real time monitoring of reagent’s and consumable’s status provide smooth and uninterrupted workflow for laboratories.

Support laboratory accreditation requirements and documentation requirements

  • Traceability info/operation log allow laboratories to trace the measurement results and the related information such as the reagent lot number, calibration curve used in testing, and the most recent date and time of QC measurement. The operation log provides audit trail of the operation, maintenance history and any setting changes in the system.
  • Onboard maintenance function automatically charted the maintenance procedures with a checklist and keep laboratories up to date with their instrument maintenance to meet laboratory accreditation requirements.

1. Shima M, Thachil J, Nair SC, Srivastava A. Towards standardization of clot waveform analysis and recommendations for its clinical applications. J Thromb Hemost. 2013; 11:1417-20.

  • PT: Dade Innovin, Thromborel S
  • APTT: Dade Actin, Dade Actin FS, Dade Actin FSL, Pathromtin SL
  • Fibrinogen: Dade Thrombin, Dade Fibrinogen Determination Reagent
  • Thrombin Time: Test Thrombin, Thromboclotin
  • Batroxobin Time: Batroxobin
  • Factor Deficiency: Factor II, V, VII, VIII, IX, X, XI, XII
  • Lupus Anticoagulant: LA1 Screen, LA2 Confirmation
  • Protein C Pathway: ProC Global, Protein C Reagent, Berichrom Protein C, Protein S Ac, Innovance Free Protein S Antigen
  • Antithrombin: Innovance Antithrombin, Berichrom Antithrombin III (A)
  • D-Dimer: Innovance D-Dimer
  • Von Willebrand Factor: vWF Ag, Innovance vWF Ac, BC von Willebrand
  • Chromogenic: Factor VIII Chromogenic, Berichrom Factor XIII Chromogenic, Berichrom C-1 Inhibitor, Berichrom α2-Antiplasmin, Berichrom Plasminogen
  • Heparin: Biophen Heparin LRT
  • Direct Thrombin Inhibitors: Hemoclot Thrombin Inhibitors, BIOPHEN DTI
  • Direct Factor Xa Inhibitors: Biophen Heparin LRT, Biophen DiXal
  • Platelet Aggregation: Revohem ADP, Revohem Collagen, Revohem Epinephrine, Revohem Arachidonic Acid, Revohem Ristocetin
CS-2500 CS-2400
Detection principles Multi-wavelength detector for transmitted light at 340, 405, 575, 660 and 800 nm Multi-wavelength detector for transmitted light at 340, 405, 575, 660 and 800 nm
Detection channel/method 10 channels for clotting, chromogenic and immunoassays (4 of these channels are also be used for platelet aggregation assays) 10 channels for clotting, chromogenic and immunoassays (4 of these channels are also be used for platelet aggregation assays)
Parameters up to 60 parameters can be analysed simultaneously up to 60 parameters can be analysed simultaneously
Throughput PT: 180 tests/h
PT/APTT: 115tests/h		 PT: 180 tests/h
PT/APTT: 115tests/h
Sampling Continuous loading of maximum 5 racks of 10 tubes each, cap-piercing functionality
5 dedicated STAT positions		 Continuous loading of maximum 5 racks of 10 tubes each, non-cap piercing functionality
5 dedicated STAT positions
Reagent holder 40 tilted reagent vial positions (10°C), 10 with mixing function
5 positions (room temperature)
All positions with positive reagent identification		 40 tilted reagent vial positions (10°C), 10 with mixing function
5 positions (room temperature)
All positions with positive reagent identification
Reference curves Maximum 10 reference curves per lot
Maximum 10 lots per parameter
Maximum 250 parameters		 Maximum 10 reference curves per lot
Maximum 10 lots per parameter
Maximum 250 parameters
Quality control X-bar control, Levy-Jennings control
Multi-rule (Westgard Rule) monitoring
750 files with maximum 1,200 data points each		 X-bar control, Levy-Jennings control
Multi-rule (Westgard Rule) monitoring
750 files with maximum 1,200 data points each
Data storage Up to 10,000 sample results with reaction curves Up to 10,000 sample results with reaction curves
Printer Graphic or Data Printer (optional) Graphic or Data Printer (optional)
Dimensions (WxHxD)/weights Main unit:
775 × 685  × 895 mm, 110  kg (approximate)Pneumatic unit:
280 × 400 × 355 mm, 17 kg (approximate)		 Main unit:
775 × 685  × 895 mm, 110  kg (approximate)Pneumatic unit:
280 × 400 × 355 mm, 17 kg (approximate)

CS Series Concept

CS 2400 Outline

Download CS-2400/2500 brochure here

Features & Benefits

The CS-2400 and CS-2500 systems perform a wide spectrum of routine and specialised testing with consistent accuracy and reliability, usability designed with Medical Technologists in mind, and provide extra support to laboratory accreditation and documentation requirements.

Consolidation of routine and specialised testing

  • The CS-2400 and CS-2500 systems automates testing of special parameters such as FXIII activity, platelet-based von Willebrand cofactor activity, platelet aggregation to ADP, epinephrine, collagen, arachidonic acid and ristocetin in a single analyser.
  • The 1st and 2nd derivatives are available from the clot waveform analysis for research in potential clinical utility of evaluating coagulation function in various bleeding disorders, especially Haemophilia A, B, and monitoring bypass therapy1.

Consistent accuracy and reliability

  • Sysmex’s proprietary multi-wavelength analysis technology automatically uses optimal wavelength for each measurement parameter to reduce the effects of interfering substances on the absorbance spectra, or in specific sample conditions such as low fibrinogen level or severe lipaemia to deliver accurate result on every test run.
  • Sample integrity such as the presence of interfering substances in the sample – haemolysis, icterus, lipaemia (HIL) and primary tube sample volume is checked before analysis. Results are flagged if the sample is of questionable quality to ensure only reliable results are reported by laboratories.

Advanced usability

  • Intuitive cap-piercing technology on the CS-2500 system allows mix of capped and uncapped tubes and cups on the same rack and reduces sample processing time.
  • Onboard capacity of up to 40 reagents (cooled at 10°C) and five additional buffer positions, accessible reagent table for continuous loading of reagents and consumables and real time monitoring of reagent’s and consumable’s status provide smooth and uninterrupted workflow for laboratories.

Support laboratory accreditation requirements and documentation requirements

  • Traceability info/operation log allow laboratories to trace the measurement results and the related information such as the reagent lot number, calibration curve used in testing, and the most recent date and time of QC measurement. The operation log provides audit trail of the operation, maintenance history and any setting changes in the system.
  • Onboard maintenance function automatically charted the maintenance procedures with a checklist and keep laboratories up to date with their instrument maintenance to meet laboratory accreditation requirements.

1. Shima M, Thachil J, Nair SC, Srivastava A. Towards standardization of clot waveform analysis and recommendations for its clinical applications. J Thromb Hemost. 2013; 11:1417-20.

Assay
  • PT: Dade Innovin, Thromborel S
  • APTT: Dade Actin, Dade Actin FS, Dade Actin FSL, Pathromtin SL
  • Fibrinogen: Dade Thrombin, Dade Fibrinogen Determination Reagent
  • Thrombin Time: Test Thrombin, Thromboclotin
  • Batroxobin Time: Batroxobin
  • Factor Deficiency: Factor II, V, VII, VIII, IX, X, XI, XII
  • Lupus Anticoagulant: LA1 Screen, LA2 Confirmation
  • Protein C Pathway: ProC Global, Protein C Reagent, Berichrom Protein C, Protein S Ac, Innovance Free Protein S Antigen
  • Antithrombin: Innovance Antithrombin, Berichrom Antithrombin III (A)
  • D-Dimer: Innovance D-Dimer
  • Von Willebrand Factor: vWF Ag, Innovance vWF Ac, BC von Willebrand
  • Chromogenic: Factor VIII Chromogenic, Berichrom Factor XIII Chromogenic, Berichrom C-1 Inhibitor, Berichrom α2-Antiplasmin, Berichrom Plasminogen
  • Heparin: Biophen Heparin LRT
  • Direct Thrombin Inhibitors: Hemoclot Thrombin Inhibitors, BIOPHEN DTI
  • Direct Factor Xa Inhibitors: Biophen Heparin LRT, Biophen DiXal
  • Platelet Aggregation: Revohem ADP, Revohem Collagen, Revohem Epinephrine, Revohem Arachidonic Acid, Revohem Ristocetin
Specifications
CS-2500 CS-2400
Detection principles Multi-wavelength detector for transmitted light at 340, 405, 575, 660 and 800 nm Multi-wavelength detector for transmitted light at 340, 405, 575, 660 and 800 nm
Detection channel/method 10 channels for clotting, chromogenic and immunoassays (4 of these channels are also be used for platelet aggregation assays) 10 channels for clotting, chromogenic and immunoassays (4 of these channels are also be used for platelet aggregation assays)
Parameters up to 60 parameters can be analysed simultaneously up to 60 parameters can be analysed simultaneously
Throughput PT: 180 tests/h
PT/APTT: 115tests/h		 PT: 180 tests/h
PT/APTT: 115tests/h
Sampling Continuous loading of maximum 5 racks of 10 tubes each, cap-piercing functionality
5 dedicated STAT positions		 Continuous loading of maximum 5 racks of 10 tubes each, non-cap piercing functionality
5 dedicated STAT positions
Reagent holder 40 tilted reagent vial positions (10°C), 10 with mixing function
5 positions (room temperature)
All positions with positive reagent identification		 40 tilted reagent vial positions (10°C), 10 with mixing function
5 positions (room temperature)
All positions with positive reagent identification
Reference curves Maximum 10 reference curves per lot
Maximum 10 lots per parameter
Maximum 250 parameters		 Maximum 10 reference curves per lot
Maximum 10 lots per parameter
Maximum 250 parameters
Quality control X-bar control, Levy-Jennings control
Multi-rule (Westgard Rule) monitoring
750 files with maximum 1,200 data points each		 X-bar control, Levy-Jennings control
Multi-rule (Westgard Rule) monitoring
750 files with maximum 1,200 data points each
Data storage Up to 10,000 sample results with reaction curves Up to 10,000 sample results with reaction curves
Printer Graphic or Data Printer (optional) Graphic or Data Printer (optional)
Dimensions (WxHxD)/weights Main unit:
775 × 685  × 895 mm, 110  kg (approximate)Pneumatic unit:
280 × 400 × 355 mm, 17 kg (approximate)		 Main unit:
775 × 685  × 895 mm, 110  kg (approximate)Pneumatic unit:
280 × 400 × 355 mm, 17 kg (approximate)
Video

CS Series Concept

CS 2400 Outline

Documents

Download CS-2400/2500 brochure here